报告题目: Highly Active Supported Catalysts

报 告 人: Yoichi M. A. Yamada (山田 阳一) 教授

报告时间: 2019年10月24日，星期四14:30

报告地点: 仲英楼B253

报告摘要

It is important to develop metalloprotein-inspired polymer-supported metal catalysts, ensuring catalytic activity, stability and reusability for safe, non-toxic, sustainable chemistry, and green organic synthesis. We have reported convoluted polymeric metal catalysts for organic transformation reactions, where a soluble linear polymer having multiple ligand groups is cross-linked with transition metals via coordinative complexation. Here, we report development of a highly active and reusable polymeric imidazole palladium catalyst MPPI-Pd. By using 0.28 mol ppm (0.000028 mol %) to 0.1 mol % of MPPI-Pd, the allylic arylation, the Suzuki-Miyaura reaction, and the Mizoroki-Heck reaction proceeded smoothly to give the corresponding coupling products in high yield. MPPI-Pd was reused without loss of catalytic activity.[1] This methodology was also applied to preparation of highly active copper catalysts[2] and others.[3,4]

参考文献

[1] (a) S. M. Sarkar, Y. Uozumi, Y. M. A. Yamada, Angew. Chem., Int. Ed. 2011, 50, 9437-9441; (b) Y. M. A. Yamada, S. M. Sarkar, Y. Uozumi, J. Am. Chem. Soc. 2012, 134, 9285-9290; (c) T. Sato, A. Ohno, S. M. Sarkar, Y. M. A. Yamada, Y. Uozumi, ChemCatChem 2015, 7, 2141-2148. d) R. Hudson, H. R. Zhang, A. LoTemplio, G. Benedetto, G. Hamasaka, Y. M. A. Yamada, J. L. Katz, Y. Uozumi, Chem. Commun., 2018, 54, 2878-2881.

[2] (a) Y. M. A. Yamada, A. Ohno, T. Sato, Y. Uozumi, Chem Eur. J. 2015, 21, 17269-17273; (b) Y. M. A. Yamada, H. Yoshida, A. Ohno, T. Sato, T. Mase, Y. Uozumi, Heterocycles 2017, 95, 715-721; (c) H. Hu, A. Ohno, T. Sato, T. Mase, Y. Uozumi, Y. M. A. Yamada, Org. Proc Res. Dev. 2019, 23, 493-498.

[3] R. Hudson, G. Hamasaka, T. Osako, Y. M. A. Yamada, C.-J. Li, Y. Uozumi, A. Moores, Green Chem. 2013, 15, 2141-2148.

[4] T. S. Symeonidis, A. Athanasoulis, R. Ishii, Y. Uozumi, Y. M. A. Yamada, I. N. Lykakis, ChemPhotoChem 2017, 1. 479-484.

报告人简介：

研究领域   非均相催化·光催化·绿色可持续化学·药物化学

教育经历

1994 东京大学 学士

1999 东京大学 博士（药学）导师：Masakatsu Shibasaki（柴崎正胜教授)

1999 帝京大学 助理教授, Shiro Ikegami 研究组

2003 美国Scripps 研究所  研究员， K.C. Nicolaou 研究组

2003 日本分子科学研究所 助教，Yasuhiro Uozumi 研究组

2007 日本理化学研究所（RIKEN) CSRS 研究中心 Deputy Team Leader, Yasuhiro Uozumi 研究组

2018 日本理化学研究所（RIKEN) CSRS 研究中心 Team Leader

2018 埼玉大学 客座教授（兼任）